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The honest summary: per-compound trial data are strong

10.1016/j.biopha.2022.113273 123 ZhangZ.GarzottoM.DavisE

Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig