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The sympathetic nervous system (SNS) provides innervation to the enteric ganglia, the circular muscles of sphincters, and the mucosa of the stomach and intestines [40]

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However, rodents and man differ in some aspects of their metabolic regulation in response to a certain diet or pharmaceutical intervention targeting the insulin/IGF-1 system

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Notably, a substantial proportion of retatrutide recipients (64-100%) were able to achieve a weight loss of 5% or more, a clinically significant threshold, compared to just 27% in the placebo group