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An improved understanding of genetic forms of disease has more recently facilitated the identification of amenable targets for novel gene therapies in subsets of patients with ALS

349-349 Fielding, R., Riede, L., Lugo, J., Bellamine, A

Nguyen TV, Damiani G, Orenstein LAV, Hamzavi I, Jemec GB

Targeting of IGF-1R to block its signalling may be obtained by interference with ligand/receptor interactions, receptor synthesis and expression, receptor TK activity, or combinations of these strategies