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OHB accumulation in hippocampal neurons reduces HDAC2/HDAC3 recruitment to the BDNF promoter, thereby increasing BDNF transcription, a key neurotrophic signal that supports learning and memory [71]

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It is not recommended for those under 18, pregnant or breastfeeding women, or individuals with medical conditions who have not consulted a doctor

Dysesthesia TRIUMPH-4 revealed a unique side effect: dysesthesia (tingling, burning, or numbness) in 20.9% of participants at 12mg (8.8% at 9mg), versus 0.7% placebo