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Safety concerns will be important to address, and clinician and patient education on this front will be crucial (e.g., how to adjust insulin doses and manage side effects)

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For obesity management, NICE has issued relevant guidance and technology appraisals that define NHS eligibility criteria which are distinct from marketing authorisation alone: NICE TA875 covers semaglutide (Wegovy) for managing overweight and obesity, with specific BMI and comorbidity eligibility criteria and requirements for specialist service involvement

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