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10.1038/nm.3762 87 KanlayaR.KhamchunS.KapincharanonC.ThongboonkerdV

In patients with malignant tumors, ctDNA mainly consists of DNA from primary or metastatic tumor cells

This can then support general antioxidant defence mechanisms and minimize oxidative stress (182)

In erythrocytes and blood plasma of patients with the complicated peptic ulcer and postgastroresection syndromes there was the increase of conjugated dienes (and in the second group the increase in antioxidant activity)

Therefore, in states of chronic under-nutrition, hepatic GH resistance is an adaptive response, as high GH levels are necessary to maintain euglycemia, while low IGF-I levels conserves energy during periods of nutritional deprivation