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7.2 Translational implications for endpoint interpretation and functional relevance From a translational perspective, the major challenge is not simply whether altered eating experience occurs, but how it should be interpreted across endpoint levels (11)

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Critical structural modifications, such as C-terminal amidation and the presence of histidine at position 7, enhance their therapeutic efficacy and extend their half-life

According to their respective PK profiles, exenatide BID and lixisenatide can be categorized as short-acting agents (each has a half-life of 35 h) compared with the long-acting agents liraglutide, exenatide LAR, albiglutide, and dulaglutide, which have half-lives ranging from 12 h to several days [16]