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4 Conclusion In conclusion, due to its multifaceted and heterogeneous nature, a personalized approach is necessary for obesity management, especially in syndromic obesity like PWS where the underlying pathophysiology remains largely unknown

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Heart failure with preserved ejection fraction and obstructive sleep apnea: a novel paradigm for additional cardiovascular benefit of SGLT2 inhibitors in subjects with or without type 2 diabetes

In principle, there are three structural units for PROTAC, which includes the E3 ligase binding motif for the recruitment of the ubiquitin-proteasome-system (UPS), a linker and a second pharmacophore for the binding of the target protein [175]