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In a study targeting suicide attempts as the endpoint, a control group with a higher prevalence of depression and suicidal ideation might lead to outcome bias, as evidenced by the increased incidence of suicidal ideation within the control group
In support, intravenous or intravitreous L-NAME application, given before, would aggravate the harmful effect of the major noxious procedure (i.e., ischemia by increasing intraocular pressure above systolic pressure by the infusion into the anterior chamber
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Its ability to modulate the inflammatory response also contributes to its effectiveness in reducing pain and promoting recovery
