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Ethics declarations Ethics approval and consent to participate All procedures described herein were approved by the Institutional Review Board for the Protection of Human Subjects of Baylor University (Protocol # 7920244) and Research Ethical Review Committee of Kyowa Hakko Kirin Co., Ltd

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Peptide What It Is What It Is Studied For (research context) GHK-Cu A naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine complexed with copper) Extracellular matrix remodeling, collagen-related gene signaling, and skin and hair follicle models BPC-157 A synthetic pentadecapeptide derived from a sequence found in gastric juice Connective-tissue and gastrointestinal repair models in animal studies TB-500 A synthetic fragment of the naturally occurring protein thymosin beta-4 Cell migration, actin regulation, and angiogenesis in tissue-repair models GHK-Cu is the most extensively documented of the three