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The effects of facial volume loss may include: sagging skin, particularly in the cheeks and jawline, hollowness around the eyes, and a rapid loss of facial volume leading to a gaunt, aged appearance

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Fidler J, Graska J, Gietler MM et al (2022) PYR/PYL/RCAR receptors play a vital role in the abscisic-acid-dependent responses of plants to external or internal stimuli

A summary of the potential perioperative improvements suggested can be found in Table 3

Gastrointestinal side effects like nausea, vomiting, diarrhea, and constipation represent the most common adverse reactions and typically happen during dose escalation [15]