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Sig Transduct Target Ther 10 , 250 (2025)

Beyond detoxification, the antioxidant machinery functions as a redox-sensitive signaling platform, mediating post-translational modifications and transcriptional reprogramming that fine-tune stress responses

In addition to insulin sensitivity, GPER influences glucose metabolism by modulating hepatic gluconeogenesis and glycogen synthesis

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however, there are scenarios where inhibiting SIRT3 might be beneficial 181