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Secondly, contamination from other metals, such as Cd and As, during Se accumulation can cause toxic stress in the plant and human health

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Chronic conditions and long-standing injuries often fall into this category

Presently, theres a lack of extensive data on the long-term safety and tolerability of high-dose, prolonged omega-3 supplementation, underscoring the need for further investigation (84)

This is particularly true for pigmented macules or patches where the pigment density is variable or where gray or black hues are present