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Yes, these medications are a tool, says Youssef

However, compounded drugs pose a higher risk to patients than FDA-approved drugs because compounded drugs do not undergo FDA premarket review for safety, effectiveness, or quality," the FDA stated

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Orlistat has traditionally been a first-line option due to its established safety profile and availability, though its modest efficacy (typically 3-5% additional weight loss beyond lifestyle intervention) and gastrointestinal side effects limit its appeal

The study included 701 patients who were administered either varying doses of oral semaglutide or a placebo over a span of 52 weeks, followed by a 5-week observation period