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P-rank scores show that SGLT-2 inhibitors were ranked first in reducing HHF (100%) (Additional file 1: Table S2)

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However, some patients may experience: Nausea Dry mouth Vivid dreams Trouble sleeping Loss of appetite Drowsiness Increased sweating Reduced sex drive Contact your doctor right away if you experience signs of serotonin syndrome (a rare but serious reaction that can include rapid heart rate, confusion, and muscle twitching), worsening anxiety, extreme mood changes, or worsening depression

Acknowledgements We thank all investigators and research teams