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Not directly, but the calorie restriction caused by GLP-1 medications can include significant lean mass loss: up to 40% of total mass lost in some studies

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Paraffin sections were then stained with hematoxylin-eosin

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In combination with insulin (with or without metformin), JANUVIA provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo (Table 14)