how deep to inject b12 Give Injections at Home to Yourself · PA Relief Treating Severe Vitamin B12 Deficiency

It takes Nicotinamide (the raw material for NAD+) and methylates it, effectively removing it from the salvage loop

Vitamin B12 There is four types of parenteral Vitamin B12 available: Cyanocobalamin 100 mcg/ml and 1000 mcg/ml best used as IM to prevent rapid loss via kidneys Hydroxycobalamin IM (compounded 1000 mcg/ml or more) known as long acting B12 (binds better to plasma proteins than cyanocobalamin) Methylcobalamin IV (compounded 1000 mcg or more up to 5000 mcg/ml) Adenosylcobalamin IV Common dose is 1000 mcg IM or IV Vitamin B12 as hydroxycobalamin is synthesized exclusively by microorganisms and is found in the liver of animals bound to protein as methylcobalamin = metabolically active form of Vitamin B12 Hydroxycobalamin is a chelator of cyanide and is used in cyanide poisoning Hydroxocobalamin is most generally used for vitamin B12 replacement therapy and is considered the drug of choice for vitamin B12 deficiency by the Martindale Extra Pharmacopoeia (Sweetman, 2002) and the World Health Organization (WHO) Model List of Essential Drugs

People on certain medications: Some medications can interfere with the absorption or metabolism of vitamin B12, including proton pump inhibitors (PPI), metformin, nitrous oxide anesthesia, some epileptic medications, and colchicine (for gout)

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Cobalequin is an easy-to-administer form of cobalamin supplementation