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This lower affinity for IGF-binding proteins allows IGF-1 LR3 to remain in its active, unbound form, where it can bind to IGF-1 receptors

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Toxicology research indicates the peptide has no lethal dose in rat models even at extremely high concentrations, and chronic administration studies show no organ toxicity or significant biochemical abnormalities

In vivo and in vitro , paeoniflorin has a wide range of pharmacological activities, including anti-inflammatory, antioxidant, immunomodulatory, analgesic, anticonvulsant, antithrombotic, neuroprotective, cardioprotective, hepatoprotective, antitumor and antidepressant effects (Zhou Y.-X