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Effect of High-Concentration Uric Acid on Nitric Oxide

HDL-induced NO underlies many of HDLs beneficial properties to endothelial cells, including HDL-induced vasodilation, tightening of cell-to-cell junctions and increased barrier function, differentiation of endothelial progenitor cells, cell survival and proliferation, cell migration, inhibition of apoptosis, and suppression of adhesion molecule expression

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n = 138,980 patients, of whom n = 2,944 were GLP-1 RA-exposed) found a trend toward increased postoperative aspiration events in GLP-1 RA-exposed patients (adjusted HR 1.28, 95% CI 0.981.67), which did not reach conventional statistical significance but is directionally consistent with biological plausibility [19]