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Abnormal estrogen signaling through ER is a major driver of tumorigenesis in luminal A and luminal B breast cancers [4], as it promotes the proliferation of cancer cells by overexpressing cyclin D1 and c-Myc, both of which enable the tumors to bypass the G1/S checkpoint [5]

Lifetime didn't divulge an official reason, although its lower-than-expected ratings were believed to have influenced their decision to let the show go and allow another platform to pick it up

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