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The CNS in humans presents considerable anatomical, immunological, and functional challenges, and ensuring that regenerated neurons integrate meaningfully into pre-existing circuits without causing maladaptive rewiring or excitotoxicity is a task of extraordinary complexity

doi:10.1177/039463200702000319

Chu RYK, et al

Identifying Candidates for Insulin Tapering Careful patient selection can identify which patients have the highest likelihood of successfully transitioning off insulin to medications such as GLP-1 agonists