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However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

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The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations

Mico JA, Rojas-Corrales MO, Gibert-Rahola J, Parellada M, Moreno D, Fraguas D et al