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In addition to movement disorder, different non-motor symptoms such as dementia, psychosis and depression are observed in patients, which increase in late stages of disease

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Supplementation with antioxidants and small molecules containing thiol groups, along with chelating agents may be beneficial in increasing toxic metal mobilization and excretion, with improvement of biochemical variables [118]

Berberine alleviates cisplatin-induced acute kidney injury by regulating mitophagy via PINK 1/Parkin pathway

The complexes induce endoplasmic reticulum (ER) stress by inhibiting ubiquitin-proteasome system (UPS) activity, leading to polyubiquitinated protein accumulation and activation of the unfolded protein response (UPR)