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However, intraorally, hyperpigmentation is more typically a consequence of physiologic, idiopathic sources, neoplasia, medications, high serum concentrations of pituitary adrenocorticotropic hormone (ACTH), postinflammatory changes, and genetic or autoimmune disorders

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Weight gain and weight-loss resistance may involve insulin response, energy expenditure, fat storage, inflammation, sleep patterns, stress hormones, genetics, and lifestyle habits

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Concentration declines with age, making it a key compound in age-related biological studies