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In NAION, that blood supply is disruptednot due to inflammation or a blocked artery, but because of insufficient circulation in the small blood vessels serving the optic nerve

Sies H, Sharov VS, Klotz LO, Briviba K

The mechanism is likely a combination of the immune response to the injected protein and the metabolic shift that occurs as the medication takes effect

Metabolic master regulators: sharing information among multiple systems

A patient who lost weight but developed fatigue, constipation, under-eating, or muscle weakness may need a different strategy than a patient who lost weight steadily, maintained strength, and improved lab markers