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Rare but serious risks include pancreatitis

Several retrospective studies and meta-analyses on the association of DPP-4 inhibitor therapy and pancreatitis have altogether shown a low risk for acute pancreatitis (46, 47)

Sun, The association between bisphenol A exposure and oxidative damage in rats/mice: a systematic review and meta-analysis

Although this method gained some advantages, the improper dosage/use of antibiotics causes further burden, leading to antibiotic resistance than treatment itself