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Indeed, ROS can oxidize methionine residues (methionine sulfoxides) within proteins and potentially impair their activities

Figure 7D, E, F ), indicating that VDAC1 may drive chemoresistance via autophagy activation

This dual nature has contributed to theoretical concerns

Food Chem Toxicol 68:290296 Liu JZ, Yao B, Siemionow V et al (2005) Fatigue induces greater brain signal reduction during sustained than preparation phase of maximal voluntary contraction