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In male F344/N rats, there were increased incidences of uncommon kidney tubular cell neoplasms, osteosarcomas of the bone, and neoplasms of the subcutaneous tissue

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Research models suggest its involvement in modulating telomerase-related activity and neuroendocrine regulatory mechanisms under controlled experimental conditions

DOI: 10.1111/jocd.12910

Most people report minimal discomfort during dermal filler injections, as a local anaesthetic or numbing cream is applied before the procedure