The starting dose is typically 2.5 mg, with gradual titration every four weeks to minimize gastrointestinal side effects and improve tolerability
In a Phase 1 randomized, double-blind clinical study targeting obese participants (NCT04478708), AMG133 demonstrated acceptable safety, tolerability, and significant dose-dependent weight loss
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kidney stones) or kidney disease Have glaucoma or other eye conditions Have liver disease Have weak or brittle bones Have breathing or lung problems Have a history of metabolic acidosis Struggle with depression, mood problems, or suicidal thoughts/behaviors Have an upcoming surgery Are on a ketogenic diet Have diarrhea Bottom line: topiramate for weight loss Topiramate can be an effective tool for weight loss, particularly when combined with lifestyle changes, such as a healthy diet and regular exercise
