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The priming signal involves the upregulation of NLRP3 expression and the synthesis of proinflammatory cytokines such as TNF- and IL-1, typically mediated by nuclear factor kappa B activation in response to inflammatory stimuli

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Other conditions, such as toxic multinodular goiter, may also cause hyperthyroidism but these other conditions are not as common as Graves disease

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21 Heriditary cystatin C amyloid angiopathy (HCCAA): Hereditary cystatin C amyloid angiopathy (HCCAA) is a rare dominantly inherited disease caused by a leucine to glutamine variant of human cystatin C (hCC)