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However, infrared sauna detoxification can support this natural process by promoting increased circulation and sweating, which some believe may aid in the removal of toxins

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PLoS Pathog 15, e1007590 pmid:30802273 30

Later, in a population with bipolar depression and insulin resistance, a proof-of-concept open-label trial found that adjunctive pioglitazone (1545 mg/day for 12 weeks) was associated with significant improvement in depressive symptoms, measured primarily with the Hamilton Depression Rating Scale (HAM-D), as well as improvements in metabolic parameters [55]