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In AD patients, lipid peroxidation plays an ambient factor in neuronal death through various mechanisms, including the inappropriate function of ion channels (Na + , K + , and Ca ++ ) for glucose transporters (Fig

However, implementation of eryptosis assays in nanotoxicology can be limited by the lack of a generally accepted single eryptosis marker and the requirements to use several markers simultaneously, their lower cost-effectiveness compared to the hemolysis assays, and the availability of the equipment, since eryptosis detection is primarily flow cytometry-based

They need to be eliminated

Key milestones to watch are phase II trials showing clinically meaningful cycle regularity, replication across diverse populations, and head-to-head comparisons with standard hormonal therapies

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