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Hypertensive disorders of pregnancy that are accompanied by proteinuria or other maternal organ dysfunction, such as acute kidney injury, are referred to as pre-eclampsia

Scientific Reports , 7 (1), 18

5HT1A receptors are known to negatively regulate serotonin neurons and are expressed as presynaptic autoreceptors in the raphe nucleus and postsynaptic receptors on cortical, hippocampus, hypothalamic and spinal regions, implicated in emotion, mood, motor activity, and stress responses (Drevets et al

This slower escalation compared to other medications reflects the triple mechanism requiring more gradual receptor adaptation

Akpek, M