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Established GLP-1 users may bypass this requirement if they have recent documentation of stable dosing

Using PCCA Suppository Bases PCCA MBK (Fatty Acid) (PCCA #30-1056) Melting fatty base Is a combination of hydrogenated vegetable oil and PEG-8-distearate (a surfactant) MucoLox (PCCA #30-4782) may be added at 10% to help with mucoadhesion Base A (Polyethylene Glycol 1450 MW, NF) (PCCA #30-1013) Dissolving PEG base Base F (Witepsol H15 ) NF (PCCA #30-4840) Melting fatty base Composed of hydrogenated coco-glycerides When using Base F in a suppository, 5% Base G (Almond Oil NF (Sweet)) (PCCA #30-1027) is added to prevent cracking PCCA Polypeg (PCCA #30-2883) Dissolving PEG base A blended polyethylene glycol suppository base with polysorbate 80

Despite its promising applications, AOD-9604 remains unapproved by the FDA for weight loss or clinical use

doi: 10.1186/s12933-020-00997-7 55 LeeDMBattsonMLJarrellDKHouSEctonKEWeirTLet al

Every patient receives individualized dosing guidance and can adjust their medication regimen as tolerance and goals evolve