In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]
If youve been feeling sluggish, foggy, or just not quite yourself, it might be time to consider a little B12 boost
More specialized markers such as methylmalonic acid or homocysteine, which can clarify borderline cases, also take weeks to shift
Increased Fertility : Vitamin B12 injections can improve fertility, which may be beneficial for those looking to start a family
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