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Early-phase clinical trials including a Phase 2 dose-ranging study published in the New England Journal of Medicine (2023) have demonstrated significant potential for weight reduction and metabolic improvement, generating considerable scientific interest

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They are viewed as an intermediate model between 2D monolayers and animal models, as they preserve key features of tumors, especially the response to drug treatments ( Treating the Th- MYCN spheroids with the DPI-MitoQ combination showed a strong synergistic effect

Tumor-associated endothelial cells with cytogenetic abnormalities