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Although it was initially regarded as a toxic gas due to its harmful effects at high concentrations, its role has been redefined following the discovery of its neuromodulatory functions in 1996, and it has since been recognized for its diverse roles, particularly in maintaining homeostasis and suppressing inflammation within the nervous, gastrointestinal, cardiovascular, renal, and hepatic systems [71,72,73,74]

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High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism

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