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Adv Exp Med Biol., 500, 535539

Nrf2 as a potential target for the treatment of epilepsy

When a GLP-1 agonist binds its receptor, it can activate two downstream pathways: cAMP (G-protein) pathway: Mediates the metabolic benefits (insulin secretion, appetite suppression, glucose control) Beta-arrestin pathway: Triggers receptor internalization and desensitization, and may contribute to nausea and vomiting Drugs that preferentially activate the cAMP pathway while minimizing beta-arrestin recruitment -- called "biased agonists" -- may maintain efficacy while reducing GI side effects

You might be an ideal candidate for medical weight loss treatment at Klinic if you have a BMI of 30 or higher, or 27 with related health issues