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Inflammatory signaling pathways

doi:10.1016/j.bbrc.2019.08.044 Fan L, Chen J, Tao Y, et al

It has been reported that some domains of ACTL6A suggest that it is a member of the actin-related gene family, which is important in proteinprotein interactions 15

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For example, emerging protein targets like IL-4, IL-10, IL-15, IL-17, IL-18, IL-23, interleukin-1 receptor-associated kinase (IRAK)-4 have been revealed to have a strong implication with innate and adaptive immune response in RA ( Protein Targets for Treatment of Rheumatoid Arthritis Currently, many agents aiming at various protein targets have been explored and tested to ease the progression of RA, and some agents have been used in the clinic to treat RA patients ( Table 1 )