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Human CHAC1 protein degrades glutathione, and mRNA induction is regulated by the transcription factors ATF4 and ATF3 and a bipartite ATF/CRE regulatory element

10.1097/IJG.0b013e31819c46b1 Sano H, Namekata K, Kimura A, et al.: Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma

The concentration of vitamin E in the brain is negatively correlated with the concentration of A in the brain (Morris et al., 2015) and can help reduce the accumulation of A in the rat brain and increase the clearance of A in the blood (Nishida et al., 2009)