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Description

In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

Lidocaine stabilizes excitable membranes by reversible blockade of voltage-gated fast sodium channels in their open and inactivated states, thereby reducing the rate of phase 0 depolarization and suppressing spontaneous impulse generation in ectopic foci