This rapid response can be especially valuable for individuals managing chronic fatigue, acute oxidative stress, or flare-ups of inflammatory conditions
SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks
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If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use entirely
Damage to the protective lining of the blood vessels ensues, as well as pathologic changes to kidney cells and kidney function