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PEA is an endogenously produced lipid mediator that helps maintain neuroimmune balance and inflammatory tone

Nature 444(7117):337342 Becatti M, Barygina V, Mannucci A, Emmi G, Prisco D, Lotti T, Fiorillo C, Taddei N (2018) Sirt1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients: a new insight into the pathogenetic mechanisms of psoriasis

Histology results Before the initiation of therapy, at 10 min after injury induction, a large hemorrhagic zone was present over the lateral and posterior white columns in all of the rats, but there were no changes in the gray matter