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Here we provide evidence that prolonged GLP-1R activation induces a robust metabolic adaptation in -cells

These medicines improve health through reduction of blood glucose and body weight, by attenuation of inflammation and via direct activation of receptors in target tissues

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However, extensive cardiovascular outcome trials have demonstrated that GLP-1 receptor agonists are safe and may even reduce cardiovascular risk

Reduced MALAT1 expression links to polycystic ovary syndrome (PCOS)-associated ovarian dysfunction, highlighting its potential as a biomarker and therapeutic target in PCOS