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(2018), Cell Metab 27(3), PubMed 29514064 Statistics from preclinical literature NAD+ (nicotinamide adenine dinucleotide), a key cofactor of redox reactions and substrate for sirtuins, PARP, CD38 , molecular weight 663.43 g/mol (not a peptide, but traditionally included in peptide research collections) Identified by Arthur Harden (Nobel Prize 1929) in 1906 as a coferment Standard experimental intravenous dose in clinical studies: 250750 mg/day for 410 days (Grant 2019, Conlon & Bird 2020) NAD+ levels decline with age by ~50 % in various tissues between ages 30 and 80 (Massudi 2012) Mechanism of supplementation: direct intravenous repletion, or precursors NR (nicotinamide riboside), NMN (nicotinamide mononucleotide) that are converted to NAD+ via NAMPT/NRK enzymes In Conlon & Bird (2020, n=11): NAD+ IV infusion 750 mg/day for 6 days raised plasma NAD+ by ~40 % over baseline NR and NMN are registered in the USA as dietary supplements (NDI status)
Health 20 (4), 3257 (2023) B.K
Gut microbiota and immune system interactions: key role in systemic inflammation Different studies discovered that the inactivation of an inflammasomes component, NOD-like receptor family pyrin domaincontaining 6 (NLRP6) protein, in mice, determines the expansion of Prevotella spp
Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study
DOI: 10.1016/j.mam.2008.09.001 51
