what is the difference between mounjaro and tirzepatide vs Semaglutide: What's Difference? Switch to Tirzepatide in T2D

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LY3298176 activated both GIP and GLP-1 receptor signaling in vitro and showed glucose-dependent insulin secretion and improved glucose tolerance by acting on both GIP and GLP-1 receptors in mice

Retatrutide : Currently in Phase 3 trials, this triple agonist (GLP-1, GIP, and glucagon receptors) has shown 24.2% average weight loss in a Phase 2 study

doi: 10.3389/fphar.2026.1808167 Received 10 February 2026 Revised 09 March 2026 Accepted 09 March 2026 Published 07 April 2026 Volume 17 - 2026 Edited by Carmen De Miguel, University of Alabama at Birmingham, United States Reviewed by Alessio Mazzieri, USL Umbria 1, Italy Ubong Ekperikpe, Icahn School of Medicine at Mount Sinai, United States Updates Copyright 2026 He, Wu and Li

Why is this called metabolic health and longevity, not just weight loss