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More importantly, overweight-fit and obese-fit women did better than normal BMI-unfit women as well as normal BMI-fit women, underscoring the fat-but-fit theory and paradox

Renal function matters as well eGFR monitoring is required, and tirzepatide specifically calls for an eGFR above 30

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This history increases the risk when taking medications that can potentially affect blood clotting, like semaglutide