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On the other hand, prolonged (16 h) stimulation with GLP-1 was shown to promote Hypoxia-Inducible Factor 1 (HIF-1) activity via induction of the mammalian Target of Rapamycin (mTOR) 16

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Therefore, to prevent NTDs, it is important to start folic acid supplementation (400 g/day) when attempting conception [165]

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