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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]

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An early analysis of pharmacovigilance data suggesting the association of glucagon-like peptide 1 receptor agonist use with an increased risk of some malignancies

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