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These effects on tumor progression and survival are accompanied by beneficial changes in immune cell infiltrates within the microenvironment

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53 Furthermore, elevated cholesterol levels in the microenvironment stimulate the expression of immune checkpoints, including PD-1, 2B4, TIM-3, and LAG-3, in T cells, driving T-cell exhaustion via the activation of the endoplasmic reticulum stress response

doi: 10.1016/j.atherosclerosis.2011.09.038